Generalized pustular psoriasis (GPP) is different from plaque psoriasis — inside and out. GPP is a rare, lifelong disease. GPP can affect your body in many different ways and not everyone will experience exactly the same symptoms. You might have painful, pus-filled blisters (called pustules), along with red, dry, cracked or scaly skin, and severe itching. GPP can also cause more general symptoms, such as fever, headache, or extreme tiredness.

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It’s not known exactly what causes GPP, but it’s important to know that GPP is not contagious.You might be naturally prone to getting it, but it can also be triggered by something in your life, such as stress, a medicine, or another disease. GPP affects more women than men. It often starts in people in their 40s, but it can occasionally occur at a younger age.